Causes Of Afib - Sanofi Heart Drug Linked to Liver Damage; Shares Slip 1% as FDA Issues Warning.
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How is Sanofi Heart Drug Linked to Liver Damage; Shares Slip 1% as FDA Issues Warning
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The US Food and Drug Administration has recently released a warning to doctors and patients that Sanofi-Aventis' (SAN) heart drug has been linked to liver damage in several patients. The SAN drug Multaq, used by patients with atrial flutter and atrial fibrillation, or irregular heart rhythms to prevent strokes, has been reported to have caused liver damage in at least two female patients who were approximately 70 years old. Multaq was approved in July 2009 by the FDA, and half a million prescriptions have been written for the drug ever since. Sanofi offices in Bridgewater, NJ could not be reached for comment. Shares have slipped 1.04% to .26.
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Causes Of Afib - Medication Guide for Cordarone (amiodarone HCl) (June 2005).
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FDA is notifying physicians and pharmacists that a Medication Guide for patients must be distributed with each prescription for Cordarone tablets, or generic amiodorone. This is an anti-arrhythmic drug used to treat severe ventricular arrhythmias. FDA requires these guides for drugs that pose a serious public health concern. The guide explains to patients that Cordarone can cause lung damage and liver damage, and in some cases can worsen the heart rhythm problems that the drug is intended to treat. It describes the warning symptoms that should lead patients to seek medical attention, and explains that the drug should only be used when other agents did not work. In a letter to health care professionals, Cordarone's manufacturer, Wyeth Laboratories, cautions that the Medication Guide should not be used as a substitute for talking to patients about the risks and benefits of the drug.
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Causes Cad - Diastolic High Blood Pressure Taken Seriously
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Do you know about - Diastolic High Blood Pressure Taken Seriously
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For blood pressure patients who wonder what those numbers mean when getting BPs, here is an explanation. Two figures are observed when taking blood pressures (e.g. 140/90). 140 stands for systolic pressure, 90 is the diastolic pressure. A normal systolic pressure should not exceed 140, and a normal diastolic pressure is no more than 90. An increase in both pressures can mean disaster.
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Systolic hypertension is different from diastolic high blood pressure. The former is characterized by sudden augmentation in the pressure of blood when the heart is contracting.
Diastolic high blood pressure on the other hand refers to the blood pressure in between muscle contractions. Doctors and medical experts have stated that diastolic high blood pressure should be taken seriously and that it causes more harm to the body than systolic does. In recent studies, persons below 65 or 70 who are diagnosed with hypertension reported increase incidents of diastolic high blood pressure. This higher rate of diastolic pressure causes adverse effects on the brain, heart and kidney. Patients of diastolic high blood pressure are advised to lower diastolic pressure by maintaining below 90. Systolic pressure is also required to be lowered though a top priority is focused on diastolic pressure.
Causes of diastolic high blood pressure include aging of the heart and its natural effects. When a person grows old his heart muscles get weary and eventually stiffen making it harder for the heart to fill in blood appropriately. Diastolic high blood pressure, if not treated well, may lead to diastolic heart failure. Diagnosis of diastolic high blood pressure may risk the patient of diseases and illnesses like CAD or coronary heart disease, aortic stenosis, hypertrophic cardiomyopathy, and other pericardial diseases.
Aside from aging, poor lifestyle like smoking and drinking, high cholesterol levels, obesity, high salt consumption, prior cardiac surgery, viral infection, family history and diabetes are also leading contributors to the occurrence of diastolic high blood pressure.
For the last 30 years, studies have also been conducted and challenged the severity of diastolic high blood pressure. In the latest issue of Archives of Internal Medicine, reports have declared that there is a great urge to control systolic pressure than diastolic pressure in hypertension patients. Elaborately, diastolic high blood pressure exposes little risk of getting other cardiovascular disorders.
In special cases of hypertension, systolic hypertension is more common than diastolic high blood pressure among elder patients. Their blood vessels have degraded resulting in the increase in systolic pressure. Advise is given to patients with these condition to lower their systolic pressure and keep it.
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Causes Of Afib - When Does a Leaking Heart Valve Mean Heart Valve Surgery?
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A leaking heart valve fortunately, does not always mean valve surgery. And, heart valve surgery, if it becomes necessary, does not always have to mean that you'll need an open-heart surgery.
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In fact, most people with a leaking valve disorder, are totally unaware of their valvular disease. Their mildly leaking valve condition goes undetected because it just never progresses to the point of needing treatment.
Symptoms which might indicate that your leaking heart valve also called valve regurgitation is worsening to the point of needing some form of treatment are: unexplained fatigue, shortness-of-breath especially when you exert yourself, heart palpitations, an awareness of your heart beat, fluttery or irregular heart beat, chest pain also referred to as angina, dizziness or fainting, and swollen ankles or feet.
The heart valves are made to move your blood through your heart in one direction. When there is valve leakage, the valve leaflets fail to close properly, and some of the blood is regurgitated backwards in the wrong direction.
In severe heart valve leakage or regurgitation, the heart has to work much harder to re-pump the blood back through your heart and into your body. This "over-work" causes enlargement of the heart.
If you begin to notice that your normal everyday activities are tiring you out, and you're experiencing one or more of the symptoms we've already mentioned, it may be time for you to visit your Doctor or cardiologist.
For example, do you notice that walking up your drive to the mail box is exhausting, or maybe just bending over to take clothes from the dryer causes chest pain, or do you experience breathlessness just from being outdoors the heat? These could all be signs of heart valve disease.
Your GP can listen to your heart with a stethoscope. Often, just listening to your heart can tell your Doctor if you have a heart murmur. Depending upon the severity of the murmur he or she hears, your GP may refer you to a cardiologist.
The cardiologist's diagnosis will probably include one or more of the following tests:
- an electrocardiogram (ECG), a test that measures the electrical activity of your heart to see how well it is working
- an echocardiogram, an ultrasound scan that produces a picture of the inside of your heart - a chest X-ray - a heart cath, a small tube (catheter) is threaded up to your heart through an artery - usually in your groin. A dye that shows up on X-rays is injected into your blood stream and X-rays are taken to produce an image of the blood flowing through your heart - a cardiac CT scan that uses X-rays to make a three-dimensional image of your heart.
If these tests show that your have a severely leaking heart valve, then, you will probably require some form of heart surgery. When possible, heart valve repair surgery is always preferable to valve replacement surgery because your own heart tissue is being used to make the repair; however, if you need a valve replacement, the artificial and pig valves are overwhelmingly successful.
As of this writing, the only approved option for treating severely leaking heart valves is open-heart surgery with heart-lung bypass. But, if your problem is a leaking mitral valve, you just might be in luck, some 30 hospitals across North America are now participating in an FDA-approved clinical study of an experimental device for repairing a leaking mitral valve, which does NOT require open-heart surgery.
This is truly exciting news! Amazingly, this minimally invasive procedure can repair a leaking mitral heart valve while the heart is still beating. In this FDA-approved clinical study, an experimental device and procedure use a catheter inserted into a vein in the groin.
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